Aspergillus fumigatus azole resistance
knowledge repository
WHY
Project lead by WUR team to promote the FAIRification of data regarding Aspergillus fumigatus and its resistance to azole-based fungicides in both agriculture and health sectors.
HOW
By developing further a tool - the FAIR-DS - with adaptations that allow scientists to more effectively manage and share their data, beyong Aspergillus.
FAIR data management
is crucial to find answers regarding current and future research in AMR, at global level
Efiicient Collaborations
are the key for optimal and apliable outcomes of your research
Impact
on your team by managing better your resources while sharing your work more easily
Why Aspergillus fumigatus?
More frequently, A. fumigatus is gaining resistance to antifungal drugs due to environmental exposure to agricultural fungicides, or prolonged clinical exposure through antifungal therapy. This results in significant health risks to the immuno-compromised population. Resistance primarily occurs via mutations in cyp51A, the target of azole antifungal drugs; the most common mutation, TR34/L98H, has been described globally.
From complex data to sharable pipelines and impact on human health
Most scientists working with Aspergillus fumigatus collect data with diverse formats, in various types of excel sheets.
To make the data adhere to FAIR standards, each dataset was examined and cleaned to fix inconsistencies in the formatting and coding.
Using Snakemake, a pipeline was made to make the monitoring data fit the FAIRDS format.
Designing the ASPAR-KR platform
With the support of D3-C2 investment theme from WUR, our team obtained funding to explore potential technical solutions to turn complex data sets regarding azole resistance in A. fumigatus into FAIR formats. The time-frame of this project was 12 months.
Showcasing ASPAR-KR project & Discussing on FAIR data
Anual conversations for realistic outcomes
Every year since 2022, the Genetics department of WUR organizes the international Azole Resistance Meeting, where we gather experts from diverse sectors and PhD students in the azole resistance field to discuss challenges and future opportunities.
Around 40 participants join the Annual Azole Resistance Meeting every year. The last meeting (November 2024) got support from NWO and gathered 41 participants from The Netherlands, Belgium, France, Germany, Hungary, Ireland, Spain, Switzerland, the USA, and the United Kingdom representing government institutions, agriculture, industry, policymakers, medicine, and environmental science.
Need help with your data?
Contact us to see how ASPAR-KR can be a helpful tool for an efficient data collection and support in its sharing with stakeholders across sectors.